Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dlx1  distal-less homeobox 1   (Synonyms: DII B, Dlx, Dlx-1)
Results	Reference
1	J:56557 Acampora D, Merlo GR, Paleari L, Zerega B, Postiglione MP, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999 Sep;126(17):3795-809
1	J:267687 Adnani L, Dixit R, Chen X, Balakrishnan A, Modi H, Touahri Y, Logan C, Schuurmans C, Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development. Biol Open. 2018 Oct 25;:bio038661
1	J:203731 Arguello A, Yang X, Vogt D, Stanco A, Rubenstein JL, Cheyette BN, Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PLoS One. 2013;8(6):e67679
1*	J:26895 Avantaggiato V, Pandolfi PP, Ruthardt M, Hawe N, Acampora D, Pelicci PG, Simeone A, Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization. J Neurosci. 1995 Jul;15(7 Pt 1):4927-42
1*	J:155785 Brinkmeier ML, Davis SW, Carninci P, MacDonald JW, Kawai J, Ghosh D, Hayashizaki Y, Lyons RH, Camper SA, Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches. Genomics. 2009 May;93(5):449-60
1*	J:13256 Bulfone A, Puelles L, Porteus MH, Frohman MA, Martin GR, Rubenstein JL, Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci. 1993 Jul;13(7):3155-72
1*	J:51598 Casarosa S, Fode C, Guillemot F, Mash1 regulates neurogenesis in the ventral telencephalon. Development. 1999 Feb;126(3):525-34
1	J:172360 Causeret F, Ensini M, Teissier A, Kessaris N, Richardson WD, Lucas de Couville T, Pierani A, Dbx1-expressing cells are necessary for the survival of the Mammalian anterior neural and craniofacial structures. PLoS One. 2011;6(4):e19367
1*	J:65298 Corbin JG, Gaiano N, Machold RP, Langston A, Fishell G, The gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development. 2000 Dec;127(23):5007-20
1	J:160856 Coremans V, Ahmed T, Balschun D, D'Hooge R, DeVriese A, Cremer J, Antonucci F, Moons M, Baekelandt V, Reumers V, Cremer H, Eisch A, Lagace D, Janssens T, Bozzi Y, Caleo M, Conway EM, Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. BMC Neurosci. 2010;11:2
1	J:316684 Ding Q, Balasubramanian R, Zheng D, Liang G, Gan L, Barhl2 Determines the Early Patterning of the Diencephalon by Regulating Shh. Mol Neurobiol. 2017 Aug;54(6):4414-4420
1*	J:206224 Dixit R, Tachibana N, Touahri Y, Zinyk D, Logan C, Schuurmans C, Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expr Patterns. 2014 Jan;14(1):42-54
1	J:205579 Dixit R, Wilkinson G, Cancino GI, Shaker T, Adnani L, Li S, Dennis D, Kurrasch D, Chan JA, Olson EC, Kaplan DR, Zimmer C, Schuurmans C, Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J Neurosci. 2014 Jan 8;34(2):539-53
1*	J:58233 Eisenstat DD, Liu JK, Mione M, Zhong W, Yu G, Anderson SA, Ghattas I, Puelles L, Rubenstein JL, DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation. J Comp Neurol. 1999 Nov 15;414(2):217-37
1	J:182786 Feng L, Eisenstat DD, Chiba S, Ishizaki Y, Gan L, Shibasaki K, Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience. 2011 Nov 10;195:9-20
1	J:59428 Fode C, Ma Q, Casarosa S, Ang SL, Anderson DJ, Guillemot F, A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 2000 Jan 1;14(1):67-80
1*	J:97076 Furushima K, Murata T, Kiyonari H, Aizawa S, Characterization of Opr deficiency in mouse brain: Subtle defects in dorsomedial telencephalon and medioventral forebrain. Dev Dyn. 2005 Apr;232(4):1056-61
1	J:44591 Garel S, Marin F, Grosschedl R, Charnay P, Ebf1 controls early cell differentiation in the embryonic striatum. Development. 1999 Dec;126(23):5285-94
1*	J:43984 Garel S, Marin F, Mattei MG, Vesque C, Vincent A, Charnay P, Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system. Dev Dyn. 1997 Nov;210(3):191-205
1	J:119561 Hirata T, Nakazawa M, Muraoka O, Nakayama R, Suda Y, Hibi M, Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Development. 2006 Oct;133(20):3993-4004
1*	J:77376 Hirata T, Nomura T, Takagi Y, Sato Y, Tomioka N, Fujisawa H, Osumi N, Mosaic development of the olfactory cortex with Pax6-dependent and -independent components. Brain Res Dev Brain Res. 2002 May 30;136(1):17-26
1	J:226834 Jones I, Hagglund AC, Tornqvist G, Nord C, Ahlgren U, Carlsson L, A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development. Dis Model Mech. 2015 Dec 1;8(12):1517-29
1*	J:32832 Kaestner KH, Schutz G, Monaghan AP, Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system. Mech Dev. 1996 Apr;55(2):221-30
1	J:98539 Kimura J, Suda Y, Kurokawa D, Hossain ZM, Nakamura M, Takahashi M, Hara A, Aizawa S, Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J Neurosci. 2005 May 25;25(21):5097-108
1	J:79871 Kitamura K, Yanazawa M, Sugiyama N, Miura H, Iizuka-Kogo A, Kusaka M, Omichi K, Suzuki R, Kato-Fukui Y, Kamiirisa K, Matsuo M, Kamijo S, Kasahara M, Yoshioka H, Ogata T, Fukuda T, Kondo I, Kato M, Dobyns WB, Yokoyama M, Morohashi K, Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet. 2002 Nov;32(3):359-69
1*	J:195139 Kraus P, Sivakamasundari V, Lim SL, Xing X, Lipovich L, Lufkin T, Making sense of Dlx1 antisense RNA. Dev Biol. 2013 Apr 15;376(2):224-35
1*	J:28661 Leussink B, Brouwer A, el Khattabi M, Poelmann RE, Gittenberger-de Groot AC, Meijlink F, Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain. Mech Dev. 1995 Jul;52(1):51-64
1*	J:44405 Liu JK, Ghattas I, Liu S, Chen S, Rubenstein JL, Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Dev Dyn. 1997 Dec;210(4):498-512
1	J:119448 Long JE, Garel S, Alvarez-Dolado M, Yoshikawa K, Osumi N, Alvarez-Buylla A, Rubenstein JL, Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. J Neurosci. 2007 Mar 21;27(12):3230-43
1*	J:173287 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
1	J:328992 Manuel M, Tan KB, Kozic Z, Molinek M, Marcos TS, Razak MFA, Dobolyi D, Dobie R, Henderson BEP, Henderson NC, Chan WK, Daw MI, Mason JO, Price DJ, Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. PLoS Biol. 2022 Sep;20(9):e3001563
1	J:23777 Monaghan AP, Grau E, Bock D, Schutz G, The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain. Development. 1995 Mar;121(3):839-53
1	J:73082 Monuki ES, Porter FD, Walsh CA, Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-lhx2 pathway. Neuron. 2001 Nov 20;32(4):591-604
1*	J:2959 Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R, Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992 Feb;8(2):241-55
1*	J:11292 Price M, Lemaistre M, Pischetola M, Di Lauro R, Duboule D, A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature. 1991 Jun 27;351(6329):748-51
1	J:166617 Sakurai Y, Kurokawa D, Kiyonari H, Kajikawa E, Suda Y, Aizawa S, Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev Biol. 2010 Nov 15;347(2):392-403
1*	J:3677 Salinas PC, Nusse R, Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres. Mech Dev. 1992 Dec;39(3):151-60
1*	J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1*	J:90405 Shinozaki K, Yoshida M, Nakamura M, Aizawa S, Suda Y, Emx1 and Emx2 cooperate in initial phase of archipallium development. Mech Dev. 2004 May;121(5):475-89
1*	J:24127 Simeone A, Acampora D, Mallamaci A, Stornaiuolo A, D'Apice MR, Nigro V, Boncinelli E, A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 1993 Jul;12(7):2735-47
1*	J:17176 Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, Boncinelli E, Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2250-4
1*	J:19476 Simeone A, D'Apice MR, Nigro V, Casanova J, Graziani F, Acampora D, Avantaggiato V, Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila. Neuron. 1994 Jul;13(1):83-101
1	J:218837 Song H, Lee B, Pyun D, Guimera J, Son Y, Yoon J, Baek K, Wurst W, Jeong Y, Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation. Dev Biol. 2015 Feb 15;398(2):280-91
1*	J:36832 Stoykova A, Fritsch R, Walther C, Gruss P, Forebrain patterning defects in Small eye mutant mice. Development. 1996 Nov;122(11):3453-65
1*	J:65195 Stoykova A, Treichel D, Hallonet M, Gruss P, Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci. 2000 Nov 1;20(21):8042-50
1	J:188110 Virolainen SM, Achim K, Peltopuro P, Salminen M, Partanen J, Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres. Development. 2012 Oct;139(20):3795-805
1	J:196218 Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein JL, Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013 May 1;521(7):1561-84
1	J:120909 Xu C, Fan CM, Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1. Mol Endocrinol. 2007 May;21(5):1234-45
1*	J:26720 Xuan S, Baptista CA, Balas G, Tao W, Soares VC, Lai E, Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron. 1995 Jun;14(6):1141-52
1	J:270427 Yabut OR, Fernandez G, Huynh T, Yoon K, Pleasure SJ, Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis. Cell Rep. 2015 Sep 29;12(12):2021-34
1	J:295961 Yabut OR, Ng HX, Yoon K, Arela JC, Ngo T, Pleasure SJ, The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling. J Neurosci. 2020 Sep 2;40(36):6872-6887
1	J:160653 Zembrzycki A, Griesel G, Stoykova A, Mansouri A, Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain. Neural Dev. 2007;2:8
1*	J:62179 Zhao Z, Stock D, Buchanan A, Weiss K, Expression of Dlx genes during the development of the murine dentition. Dev Genes Evol. 2000 May;210(5):270-5